4 - layer HIV specific dendrimers have been hybridized to blots containing HIV DNA and probed with labeled HIV specific and dendrimer specific oligonucleotides. The various labels evaluated were radioactive phosphorus, biotin, digoxigenin, and alkaline phosphatase. The signals of blots that were probed using oligonucleotides with dendrimers showed amplification of over 100 fold when compared to identical blots probed with HIV specific oligonucleotide alone. The results of several blot experiments are documented on the following pages.

4 Layer

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Polyprobe ™ DNA Dendrimers and DNA Matrix Technology are covered under U.S. Patent No's 5,175,270 || 5,484,904, || 5,487,973 and patents pending.

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